Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Ctnnb1tm2Kem
Name:	catenin beta 1; targeted mutation 2, Rolf Kemler
MGI ID:	MGI:2148567
Synonyms:	B-cateninfl2-6, BcatLOF, Beta-Catc, beta-cateninc, beta-catenindeltaex2-6-fl, beta-cateninf, beta-cateninfl, beta-cateninflox, beta-cateninfloxed, beta-cateninlox, beta-catenin/loxP(ex2-6), beta-catex2-6, beta-catfl, beta-Catflox, beta-catlof, betaCatN, beta-Ctnfl, Catnb1tm2Kem, Catnbfx, Catnblox(ex2-6), Catnbtm2Kem, Catnbtm2Kwem, CtnbfloxE2-E6, Ctnnb1f, Ctnnb1fl, Ctnnb1flox, Ctnnb1floxed, Ctnnb1fx, Ctnnb1loxp
Gene:	Ctnnb1  Location: Chr9:120762466-120789573 bp, + strand  Genetic Position: Chr9, 72.19 cM
Alliance:	Ctnnb1tm2Kem page

Germline Transmission:	Earliest citation of germline transmission: J:67966
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted in intron 1 and a loxP-flanked neomycin-TK cassette was inserted downstream in intron 6. The neomycin-TK cassette was removed by transient transfection with a Cre recombinase expression vector in ES cells prior to the production of chimeric mice and left two loxP sites flanking a region of gene sequence from exon 2 through exon 6. (J:67966)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	402 assay results 13 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	101 anatomical structure(s)

List all tumor models in MMHCdb carrying Ctnnb1tm2Kem

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ctnnb1 Mutation:	49 strains or lines available

Original:	J:67966 Brault V, et al., Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development. 2001 Apr;128(8):1253-64
All:	536 reference(s)