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Ctnnb1tm2Wbm
Targeted Allele Detail
Summary
Symbol: Ctnnb1tm2Wbm
Name: catenin beta 1; targeted mutation 2, Walter Birchmeier
MGI ID: MGI:2148591
Synonyms: beta-catlacZ(neo)
Gene: Ctnnb1  Location: Chr9:120762466-120789573 bp, + strand  Genetic Position: Chr9, 72.19 cM
Alliance: Ctnnb1tm2Wbm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60391
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation details: A lacZ gene was inserted in-frame into the gene, fused to the endogenous transcription start site. A neomycin selection cassette followed the lacZ gene. Northern blot analysis on RNA derived from homozygous ES cells demonstrated that no detectable transcript was produced from this allele, and western blot analysis on homozygous ES cells confirmed that no stable protein is produced from this allele (data not shown). (J:60391)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctnnb1 Mutation:  49 strains or lines available
References
Original:  J:60391 Huelsken J, et al., Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol. 2000 Feb 7;148(3):567-78
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory