Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Krt14tm1.1(cre)Wbm
Name:	keratin 14; targeted mutation 1.1, Walter Birchmeier
MGI ID:	MGI:2148597
Synonyms:	K14-cre(deltaneo)
Gene:	Krt14  Location: Chr11:100093988-100098336 bp, - strand  Genetic Position: Chr11, 63.43 cM, cytoband D
Alliance:	Krt14tm1.1(cre)Wbm page

Germline Transmission:	Earliest citation of germline transmission: J:69463
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Krt14tm1.1(cre)Wbm expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Krt14 (MGI:96688)   Mutation details: A cre gene was inserted in frame into the gene immediately following the endogenous start codon. An frt-flanked neomycin selection cassette that was inserted following the cre gene was removed by Flp-mediated recombination in ES cells prior to production of chimeric mice. This promoter is active after birth in the epidermis and hair follicles as well as the eye, tongue, and esophagus. (J:69463)

Activity:	Tissue activity of this recombinase allele
Driver:	Krt14 (mouse) Summary of all recombinase alleles driven by Krt14. Comparative matrix view of recombinase activities Alliance mouse Krt14 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results 1 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Krt14tm1.1(cre)Wbm

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Krt14 Mutation:	38 strains or lines available

Original:	J:69463 Huelsken J, et al., beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell. 2001 May 18;105(4):533-45
All:	18 reference(s)