About   Help   FAQ
Ephb3tm1Kln
Targeted Allele Detail
Summary
Symbol: Ephb3tm1Kln
Name: Eph receptor B3; targeted mutation 1, Rudiger Klein
MGI ID: MGI:2149669
Synonyms: EphB3-, EphB3KO, sek4-
Gene: Ephb3  Location: Chr16:21023530-21042054 bp, + strand  Genetic Position: Chr16, 12.62 cM, cytoband B1-B4
Alliance: Ephb3tm1Kln page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:37095
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Replacement of four exons and part of a fifth exon containing sequences encoding part of the kinase domain with a PGK-neomycin resistance cassette. RT-PCR studies did not detect any transcript containing the sequences encoding the kinase domain or the juxtamembrane domain in E16.5 embryonic heads of homozygous mutant mice. (J:37095)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 53 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ephb3 Mutation:  52 strains or lines available
References
Original:  J:37095 Orioli D, et al., Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J. 1996 15;15(22):6035-49
All:  56 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory