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Ephb3tm1Kln
Targeted Allele Detail
Summary
Symbol: Ephb3tm1Kln
Name: Eph receptor B3; targeted mutation 1, Rudiger Klein
MGI ID: MGI:2149669
Synonyms: EphB3-, EphB3KO, sek4-
Gene: Ephb3  Location: Chr16:21023530-21042054 bp, + strand  Genetic Position: Chr16, 12.62 cM, cytoband B1-B4
Alliance: Ephb3tm1Kln page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:37095
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Replacement of four exons and part of a fifth exon containing sequences encoding part of the kinase domain with a PGK-neomycin resistance cassette. RT-PCR studies did not detect any transcript containing the sequences encoding the kinase domain or the juxtamembrane domain in E16.5 embryonic heads of homozygous mutant mice. (J:37095)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 53 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ephb3 Mutation:  52 strains or lines available
References
Original:  J:37095 Orioli D, et al., Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J. 1996 15;15(22):6035-49
All:  56 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory