Hes1<tm1Fgu> Targeted Allele Detail MGI Mouse (MGI:2149672)

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Hes1^tm1Fgu
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Hes1^tm1Fgu
Name:	hes family bHLH transcription factor 1; targeted mutation 1, Francois Guillemot
MGI ID:	MGI:2149672
Synonyms:	Hes1-
Gene:	Hes1 Location: Chr16:29883259-29886614 bp, + strand Genetic Position: Chr16, 21.09 cM
Alliance:	Hes1^tm1Fgu page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:30431
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A PGK-neomycin resistance cassette replaced the first three exons including sequences encoding the bHLH region of HES1. Northern blot analysis did not detect transcript in E9.5 homozygous mutant embryos. (J:30431)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	386 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	25 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Hes1 Mutation:	23 strains or lines available

References

Original:	J:30431 Ishibashi M, et al., Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev. 1995 Dec 15;9(24):3136-48
All:	74 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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