Hes5<tm1Fgu> Targeted Allele Detail MGI Mouse (MGI:2149674)

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Hes5^tm1Fgu
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Hes5^tm1Fgu
Name:	hes family bHLH transcription factor 5; targeted mutation 1, Francois Guillemot
MGI ID:	MGI:2149674
Synonyms:	Hes5-
Gene:	Hes5 Location: Chr4:155045380-155046828 bp, + strand Genetic Position: Chr4, 86.01 cM
Alliance:	Hes5^tm1Fgu page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:54662
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A PGK-neomycin resistance cassette replaced 724 bp of sequence including the region that encodes the bHLH domain (Met1 to Ala76). (J:62024)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	99 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Hes5 Mutation:	16 strains or lines available

References

Original:	J:54662 Ohtsuka T, et al., Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J. 1999 Apr 15;18(8):2196-207
All:	35 reference(s)

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