Aqp3<tm1Ask> Targeted Allele Detail MGI Mouse (MGI:2150021)

Aqp3^tm1Ask
Targeted Allele Detail

Summary

Symbol:	Aqp3^tm1Ask
Name:	aquaporin 3; targeted mutation 1, Alan S Verkman
MGI ID:	MGI:2150021
Synonyms:	AQP3-
Gene:	Aqp3 Location: Chr4:41092724-41098183 bp, - strand Genetic Position: Chr4, 20.94 cM, cytoband B1
Alliance:	Aqp3^tm1Ask page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:61675
Parent Cell Line:	CB1-4 (ES Cell)
Strain of Origin:	C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A 1.3kb neomycin resistance cassette replaced parts of exons 2 and 3 of the gene. Northern blots of kidneys from homozygous mutant mice had no detectable Aqp3 transcript. Immunofluorescence analysis of fixed frozen kidney sections from homozygous mutant mice had no detectable Aqp3 protein. (J:61675)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Aqp3 Mutation:	28 strains or lines available

References

Original:	J:61675 Ma T, et al., Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4386-91
All:	37 reference(s)

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