Fgf8<tm1.3Mrt> Targeted Allele Detail MGI Mouse (MGI:2150347)

Fgf8^tm1.3Mrt
Targeted Allele Detail

Summary

Symbol:	Fgf8^tm1.3Mrt
Name:	fibroblast growth factor 8; targeted mutation 1.3, Gail R Martin
MGI ID:	MGI:2150347
Synonyms:	Fgf8^clc, Fgf8^fl, Fgf8^flox
Gene:	Fgf8 Location: Chr19:45725237-45731354 bp, - strand Genetic Position: Chr19, 38.75 cM, cytoband C3-D
Alliance:	Fgf8^tm1.3Mrt page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:45909
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1^b-m3

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: This allele is a derivative of Fgf8^tm1.1Mrt in which mice carrying this allele were mated to beta-actin Flp mice, which resulted in heterozygous offspring carrying a recombined Fgf8 allele in which the neomycin resistance cassette was deleted, and exons 2 and 3 remained flanked by loxP sites. (J:45909)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	157 assay results
In Structures Affected by this Mutation:	43 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Fgf8 Mutation:	21 strains or lines available

Notes

One of three alleles produced using a targeting construct capable of inducing different allelic variants when mated to mice that express cre, flp, or both. Referred to in the literature as Fgf8^flox, Flp mediated recombinase reverts the hypomorphic Fgf8^neo allele to wild-type (J:45909).

References

Original:	J:45909 Meyers EN, et al., An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet. 1998 Feb;18(2):136-41
All:	49 reference(s)

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