Fgf8<tm1.4Mrt> Targeted Allele Detail MGI Mouse (MGI:2150348)

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Fgf8^tm1.4Mrt
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Fgf8^tm1.4Mrt
Name:	fibroblast growth factor 8; targeted mutation 1.4, Gail R Martin
MGI ID:	MGI:2150348
Synonyms:	Fgf8-, Fgf8^del, Fgf8^delta, Fgf8^delta2,3, Fgf8^null
Gene:	Fgf8 Location: Chr19:45725237-45731354 bp, - strand Genetic Position: Chr19, 38.75 cM, cytoband C3-D
Alliance:	Fgf8^tm1.4Mrt page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:45909
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1^b-m3

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: This allele is a derivative of Fgf8^tm1.3Mrt in which mice carrying this allele were mated to beta-actin cre mice, which resulted in heterozygous offspring carrying a recombined Fgf8 allele in which both the neomycin resistance cassette and exons 2 and 3 were deleted. (J:45909)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	142 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	34 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Fgf8 Mutation:	21 strains or lines available

References

Original:	J:45909 Meyers EN, et al., An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet. 1998 Feb;18(2):136-41
All:	57 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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