Eya1<tm1Rilm> Targeted Allele Detail MGI Mouse (MGI:2150426)

Eya1^tm1Rilm
Targeted Allele Detail

Summary

Symbol:	Eya1^tm1Rilm
Name:	EYA transcriptional coactivator and phosphatase 1; targeted mutation 1, Richard Maas
MGI ID:	MGI:2150426
Synonyms:	Eya1-
Gene:	Eya1 Location: Chr1:14239178-14380459 bp, - strand Genetic Position: Chr1, 4.31 cM
Alliance:	Eya1^tm1Rilm page

Spectrum of abnormalities of great artery patterning in mice with null mutation of one or both copies of Six1^tm1Mair and Eya1^tm1Rilm

Show the 5 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:57313
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		A neomycin cassette replaced exons 10-13, encoding 153 residues of the Eya domain. (J:57313)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	195 assay results
In Structures Affected by this Mutation:	55 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Eya1 Mutation:	56 strains or lines available

References

Original:	J:57313 Xu PX, et al., Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet. 1999 Sep;23(1):113-7
All:	29 reference(s)

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