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Optc Gene Detail
Summary
  • Symbol
    Optc
  • Name
    opticin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151113
    NCBI Gene: 269120
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:133824937-133835737 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 58.02 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    386 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151113
 protein coding gene Chr1:133824937-133837344 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016494
 protein coding gene Chr1:137528182-137538965 (-)
A/J MGP_AJ_G0016477
 protein coding gene Chr1:132361015-132371811 (-)
AKR/J MGP_AKRJ_G0016442
 protein coding gene Chr1:136303361-136314271 (-)
BALB/cJ MGP_BALBcJ_G0016437
 protein coding gene Chr1:132692886-132703684 (-)
C3H/HeJ MGP_C3HHeJ_G0016263
 protein coding gene Chr1:136402751-136414601 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016898
 protein coding gene Chr1:142554168-142564968 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014609
 protein coding gene Chr1:125506327-125518169 (-)
CAST/EiJ MGP_CASTEiJ_G0015843
 protein coding gene Chr1:135449142-135460043 (-)
CBA/J MGP_CBAJ_G0016236
 protein coding gene Chr1:147446457-147457253 (-)
DBA/2J MGP_DBA2J_G0016342
 protein coding gene Chr1:131375175-131385975 (-)
FVB/NJ MGP_FVBNJ_G0016341
 protein coding gene Chr1:129997736-130008526 (-)
LP/J MGP_LPJ_G0016413
 protein coding gene Chr1:138797302-138808100 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016366
 protein coding gene Chr1:153189162-153201571 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016934
 protein coding gene Chr1:136027526-136039401 (-)
PWK/PhJ MGP_PWKPhJ_G0015629
 protein coding gene Chr1:130384012-130394902 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015416
 protein coding gene Chr1:134995074-135005825 (-)
WSB/EiJ MGP_WSBEiJ_G0015906
 protein coding gene Chr1:136056530-136067312 (-)



Homology
more
  • Human Ortholog
    OPTC, opticin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OPTC, opticin
  • Synonyms
    OPT
  • Links
    NCBI Gene ID: 26254
    neXtProt AC: NX_Q9UBM4
    UniProt: Q9UBM4

  • Chr Location
    1q32.1; chr1:203494121-203508949 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased preretinal neovascularization in an oxygen-induced retinopathy model.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    8
  • cDNA Data
    8
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000010311 Ensembl Gene Model | MGI Sequence Detail 10801 C57BL/6J ±  kb
    transcript ENSMUST00000124051 Ensembl | MGI Sequence Detail 1885 Not Applicable  
    polypeptide ENSMUSP00000120568 Ensembl | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 4
      cDNA 9
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory