Sox10<tm1Weg> Targeted Allele Detail MGI Mouse (MGI:2151173)

Sox10^tm1Weg
Targeted Allele Detail

Summary

Symbol:	Sox10^tm1Weg
Name:	SRY (sex determining region Y)-box 10; targeted mutation 1, Michael Wegner
MGI ID:	MGI:2151173
Synonyms:	Sox10-, Sox10^lacZ, Sox10LacZ^KO
Gene:	Sox10 Location: Chr15:79039113-79048690 bp, - strand Genetic Position: Chr15, 37.7 cM
Alliance:	Sox10^tm1Weg page

Lack of pigmentation and megacolon in Sox10^gt/Sox10^tm1Weg pups

Show the 4 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:67383
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: In-frame insertion of a lacZ-neomycin resistance cassette replaced the coding sequences. RT-PCR studies did not detect wild-type transcript in homozygous E12.5 embryos. (J:67383)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	905 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Sox10 Mutation:	33 strains or lines available

References

Original:	J:67383 Britsch S, et al., The transcription factor Sox10 is a key regulator of peripheral glial development. Genes Dev. 2001 Jan 1;15(1):66-78
All:	61 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24