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Hoxb3tm1Mrc
Targeted Allele Detail
Summary
Symbol: Hoxb3tm1Mrc
Name: homeobox B3; targeted mutation 1, Mario R Capecchi
MGI ID: MGI:2151773
Synonyms: Hoxb3-
Gene: Hoxb3  Location: Chr11:96214152-96238756 bp, + strand  Genetic Position: Chr11, 59.84 cM
Alliance: Hoxb3tm1Mrc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45337
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A 225 bp fragment of the gene encoding the entire homeobox domain was replaced with a neomycin cassette. (J:45337)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxb3 Mutation:  16 strains or lines available
References
Original:  J:45337 Manley NR, et al., Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures. Dev Biol. 1997 Dec 15;192(2):274-88
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory