About   Help   FAQ
Tgs1 Gene Detail
Summary
  • Symbol
    Tgs1
  • Name
    trimethylguanosine synthase 1
  • Synonyms
    D4Ertd800e, Ncoa6ip, Pimt
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151797
    NCBI Gene: 116940
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:3574875-3616619 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 1.99 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    823 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151797
 protein coding gene Chr4:3574875-3616624 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028022
 protein coding gene Chr4:38558-80859 (+)
A/J MGP_AJ_G0027980
 protein coding gene Chr4:52260-95356 (+)
AKR/J MGP_AKRJ_G0027946
 protein coding gene Chr4:41970-83221 (+)
BALB/cJ MGP_BALBcJ_G0027992
 protein coding gene Chr4:33546-75712 (+)
C3H/HeJ MGP_C3HHeJ_G0027722
 protein coding gene Chr4:197163-237532 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028435
 protein coding gene Chr4:120554-167216 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025779
 protein coding gene Chr4:33494-75132 (+)
CAST/EiJ MGP_CASTEiJ_G0027175
 protein coding gene Chr4:48206-89738 (+)
CBA/J MGP_CBAJ_G0027697
 protein coding gene Chr4:39833-80803 (+)
DBA/2J MGP_DBA2J_G0027837
 protein coding gene Chr4:51147-92187 (+)
FVB/NJ MGP_FVBNJ_G0027804
 protein coding gene Chr4:24933-65949 (+)
LP/J MGP_LPJ_G0027948
 protein coding gene Chr4:90069-132843 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027837
 protein coding gene Chr4:190164-239882 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028494
 protein coding gene Chr4:46573-89477 (+)
PWK/PhJ MGP_PWKPhJ_G0026898
 protein coding gene Chr4:188487-230479 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026727
 protein coding gene Chr4:39698-81007 (+)
WSB/EiJ MGP_WSBEiJ_G0027255
 protein coding gene Chr4:144775-185684 (+)



Homology
more
  • Human Ortholog
    TGS1, trimethylguanosine synthase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGS1, trimethylguanosine synthase 1
  • Synonyms
    NCOA6IP, PIMT, PIPMT
  • Links
    NCBI Gene ID: 96764
    neXtProt AC: NX_Q96RS0
    UniProt: Q96RS0

  • Chr Location
    8q12.1; chr8:55773446-55826445 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display complete lethality around implantation with embryonic growth arrest, impaired hatching from the zona pellucida, and increased apoptosis. Null MEFs display G2 arrest.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    45
  • cDNA Data
    103
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028233 Ensembl Gene Model | MGI Sequence Detail 41745 C57BL/6J ±  kb
    transcript ENSMUST00000052712 Ensembl | MGI Sequence Detail 4327 Not Applicable  
    polypeptide ENSMUSP00000054112 Ensembl | MGI Sequence Detail 853 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 103
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1289226
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:329543 Blandino-Rosano M, et al., Trimethylguanosine synthase 1 is a novel regulator of pancreatic beta-cell mass and function. J Biol Chem. 2022 Jan 15;298(3):101592
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory