Msh6<tm1Htr> Targeted Allele Detail MGI Mouse (MGI:2151803)

Msh6^tm1Htr
Targeted Allele Detail

Summary

Symbol:	Msh6^tm1Htr
Name:	mutS homolog 6; targeted mutation 1, Hein te Riele
MGI ID:	MGI:2151803
Gene:	Msh6 Location: Chr17:88282490-88298320 bp, + strand Genetic Position: Chr17, 57.87 cM
Alliance:	Msh6^tm1Htr page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:59561
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Part of exon 4 was replaced with a vector containing the puromycin resistance gene. (J:59561)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Tumor Data

List all tumor models in MMHCdb carrying Msh6^tm1Htr

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Msh6 Mutation:	52 strains or lines available

References

Original:	J:59561 de Wind N, et al., HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. Nat Genet. 1999 Nov;23(3):359-62
All:	6 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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