Pcdh15av-Tg2742Rpw
Transgenic Allele Detail
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| Symbol: |
Pcdh15av-Tg2742Rpw |
| Name: |
protocadherin 15; transgenic, nonhomologous insert 2742, Richard P Woychik |
| MGI ID: |
MGI:2151877 |
| Synonyms: |
av-Tg, avTgN2742Rpw, Pcdh15av-Tg, TgN(Imw)2724Rpw |
| Gene: |
Pcdh15 Location: Chr10:72935174-74485569 bp, + strand Genetic Position: Chr10, 37.43 cM
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| Alliance: |
Pcdh15av-Tg2742Rpw page
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| Transgene Type: |
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Transgenic |
| Mutation: |
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Insertion
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Mutation details: A construct consisting of a human beta-actin promoter driving expression of a rat lectin cDNA was injected into fertilized eggs. The construct integrated in multiple tandem copies into the coding region of the Pcdh15 gene, disupting the coding seqence for the fourth cdh domain. Truncated transcripts are produced from this allele that are smaller than normal size due to the SV40 poly(A) site that is present in the transgene.
(J:66738)
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| Inheritance: |
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Recessive |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Pcdh15 Mutation: |
135 strains or lines available
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| Original: |
J:56493 Alagramam KN, et al., A new mouse insertional mutation that causes sensorineural deafness and vestibular defects. Genetics. 1999 Aug;152(4):1691-9 |
| All: |
9 reference(s) |
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Analysis Tools
