Mttp<tm1Sgy> Targeted Allele Detail MGI Mouse (MGI:2152201)

Mttp^tm1Sgy
Targeted Allele Detail

Summary

Symbol:	Mttp^tm1Sgy
Name:	microsomal triglyceride transfer protein; targeted mutation 1, Stephen G Young
MGI ID:	MGI:2152201
Gene:	Mttp Location: Chr3:137795616-137849179 bp, - strand Genetic Position: Chr3, 64.06 cM
Alliance:	Mttp^tm1Sgy page

Phenotype of Mttp^tm1Sgy/Mttp^tm1Sgy and wild-type embryos at E9.5

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:48934
Parent Cell Line:	RF8 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: An in-frame GFP gene and neomycin cassette replaced most of exon 1. No mRNA was detected by RNase protection assay in samples derived from liver and yolk sac from homozygous mice. (J:48934)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Mttp Mutation:	53 strains or lines available

References

Original:	J:48934 Raabe M, et al., Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8686-91
All:	4 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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