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Taf4 Gene Detail
Summary
  • Symbol
    Taf4
  • Name
    TATA-box binding protein associated factor 4
  • Synonyms
    Taf2c1, Taf4a, TAFII130, TAFII135
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152346
    NCBI Gene: 228980
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:179553945-179618439 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 102.42 cM, cytoband H4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1176 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152346
 protein coding gene Chr2:179553945-179618519 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026981
 protein coding gene Chr2:186393666-186466187 (-)
A/J MGP_AJ_G0026947
 protein coding gene Chr2:178745314-178812210 (-)
AKR/J MGP_AKRJ_G0026917
 protein coding gene Chr2:184085159-184156497 (-)
BALB/cJ MGP_BALBcJ_G0026956
 protein coding gene Chr2:179209544-179275212 (-)
C3H/HeJ MGP_C3HHeJ_G0026697
 protein coding gene Chr2:184444376-184512719 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027402
 protein coding gene Chr2:191791285-191860574 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024769
 protein coding gene Chr2:169436812-169499467 (-)
CAST/EiJ MGP_CASTEiJ_G0026156
 protein coding gene Chr2:182681918-182751225 (-)
CBA/J MGP_CBAJ_G0026674
 protein coding gene Chr2:198721931-198808916 (-)
DBA/2J MGP_DBA2J_G0026812
 protein coding gene Chr2:177843622-177908596 (-)
FVB/NJ MGP_FVBNJ_G0026778
 protein coding gene Chr2:176442453-176507607 (-)
LP/J MGP_LPJ_G0026913
 protein coding gene Chr2:186385438-186455879 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026797
 protein coding gene Chr2:201389279-201459789 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027461
 protein coding gene Chr2:184053015-184120250 (-)
PWK/PhJ MGP_PWKPhJ_G0025892
 protein coding gene Chr2:175345152-175412192 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025692
 protein coding gene Chr2:180540471-180611652 (-)
WSB/EiJ MGP_WSBEiJ_G0026228
 protein coding gene Chr2:185025323-185094830 (-)



Homology
more
  • Human Ortholog
    TAF4, TATA-box binding protein associated factor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAF4, TATA-box binding protein associated factor 4
  • Synonyms
    MRD73, TAF2C, TAF2C1, TAF4A, TAF(II)130, TAFII-130, TAFII130, TAF(II)135, TAFII-135, TAFII135
  • Links
    NCBI Gene ID: 6874
    neXtProt AC: NX_O00268
    UniProt: O00268

  • Chr Location
    20q13.33; chr20:61953469-62065881 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TAF4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for deletions of this marker die embryonically sometime around E9.5. Conditional expression of this allele in the epidermis causes skin barrier defects and defects in hair growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    19
  • cDNA Data
    44
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039117 Ensembl Gene Model | MGI Sequence Detail 64495 C57BL/6J ±  kb
    transcript ENSMUST00000041618 Ensembl | MGI Sequence Detail 4416 Not Applicable  
    polypeptide ENSMUSP00000038610 Ensembl | MGI Sequence Detail 1042 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR009072 Histone-fold
      IPR003894 TAFH/NHR1
      IPR037249 TAFH/NHR1 domain superfamily
      IPR045144 Transcription initiation factor TFIID component TAF4
      IPR007900 Transcription initiation factor TFIID component TAF4, C-terminal
    • GlyGen
      E9QAP7 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 44
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138960
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 10
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:71679 Freiman RN, et al., Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development. Science. 2001 Sep 14;293(5537):2084-7
    • Latest
      J:333939 Saisa-Borreill S, et al., General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions. Cell Death Differ. 2023 Mar;30(3):839-853
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory