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Adora2atm1Map
Targeted Allele Detail
Summary
Symbol: Adora2atm1Map
Name: adenosine A2a receptor; targeted mutation 1, Marc Parmentier
MGI ID: MGI:2152583
Synonyms: A2AAR-, A2AKO, A2aR-
Gene: Adora2a  Location: Chr10:75152711-75170618 bp, + strand  Genetic Position: Chr10, 38.52 cM, cytoband B5.3
Alliance: Adora2atm1Map page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42276
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Part of exon 1 was replaced with a neomycin selection cassette. Northern blotting and in situ hybridization experiments confirmed that no detectable transcript is produced from this allele. (J:42276)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adora2a Mutation:  40 strains or lines available
References
Original:  J:42276 Ledent C, et al., Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor [see comments]. Nature. 1997 Aug 14;388(6643):674-8
All:  73 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory