Pkd1tm1Rsa
Targeted Allele Detail
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| Symbol: |
Pkd1tm1Rsa |
| Name: |
polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Richard Sandford |
| MGI ID: |
MGI:2152589 |
| Synonyms: |
Pkd1del17-21betageo, Pkd1del17-21betageo- |
| Gene: |
Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
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| Alliance: |
Pkd1tm1Rsa page
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Abnormal skeletal development in Pkd1tm1Rsa/Pkd1tm1Rsa mice
Show the 3 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:72238
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| Parent Cell Line: |
AK7 (ES Cell)
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| Strain of Origin: |
129S4/SvJaeSor
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutation: |
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Disruption caused by insertion of vector
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Mutation details: A promoterless IRES-LacZ-neomycin resistance cassette containing a 5' En-2 intron and splice acceptor site replaced exons 17-21. Northern analysis of homozygous mutant E12.5 embryos using an exon 15 probe detected a 12.5kb fusion transcript, and did not detect the wild-type transcript. Western analysis using an anti-beta-galactosidase antibody detected the predicted 146kDa beta-galactosidase-neomycin fusion protein in homozygous mutant embryos.
(J:72238)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Pkd1 Mutation: |
154 strains or lines available
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| Original: |
J:72238 Boulter C, et al., Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12174-9 |
| All: |
3 reference(s) |
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Analysis Tools
