Gnao1<tm1Lbi> Targeted Allele Detail MGI Mouse (MGI:2152685)

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Gnao1^tm1Lbi
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Gnao1^tm1Lbi
Name:	guanine nucleotide binding protein, alpha O; targeted mutation 1, Lutz Birnbaumer
MGI ID:	MGI:2152685
Synonyms:	Gnao1.1^tm1LBi, Go1alpha
Gene:	Gnao1 Location: Chr8:94537213-94696016 bp, + strand Genetic Position: Chr8, 45.94 cM
Alliance:	Gnao1^tm1Lbi page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:46898
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: The neo cassette was inserted into exon 6. No protein was detected in homogenates from homozygous targeted mice by ADP-ribosylation with pertussis toxin. (J:46898)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Gnao1 Mutation:	29 strains or lines available

References

Original:	J:46898 Jiang M, et al., Multiple neurological abnormalities in mice deficient in the G protein Go. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3269-74
All:	15 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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