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Gnat1tm1Clma
Targeted Allele Detail
Summary
Symbol: Gnat1tm1Clma
Name: G protein subunit alpha transducin 1; targeted mutation 1, C L Makino
MGI ID: MGI:2152779
Synonyms: alpha-t-rod, Gnat1-, Gnat1a-, Gnat1tm1Jl, Tr-, Tralpha-, trans-, transducin alpha-
Gene: Gnat1  Location: Chr9:107551636-107556833 bp, - strand  Genetic Position: Chr9, 58.86 cM
Alliance: Gnat1tm1Clma page
Severe retinal degeneration in Rhotm2.1Kpal/Rhotm2.1Kpal Gnat1tm1Clma/Gnat1tm1Clma mice and less severe degeneration in Rhotm2.1Kpal/Rhotm2.1Kpal Lrattm1Kpal/Lrattm1Kpal mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66420
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exons 4 and 5 and parts of exons 3 and 6. RT-PCR analysis revealed no transcript in total RNA derived from retinas of homozygous animals. Western analysis confirmed the absence of protein expression in homozygous mice. (J:66420)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gnat1 Mutation:  20 strains or lines available
References
Original:  J:66420 Calvert PD, et al., Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13913-8
All:  126 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory