Dnah11tm1Ssp
Targeted Allele Detail
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| Symbol: |
Dnah11tm1Ssp |
| Name: |
dynein, axonemal, heavy chain 11; targeted mutation 1, S Steven Potter |
| MGI ID: |
MGI:2152963 |
| Synonyms: |
lrd -, lrddeltaP1 |
| Gene: |
Dnah11 Location: Chr12:117841717-118162778 bp, - strand Genetic Position: Chr12, 63.25 cM
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| Alliance: |
Dnah11tm1Ssp page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:44522
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin selection cassette replaced a genomic fragemnt that contained two exons that encode the first P-loop. RT-PCR analysis on RNA derived from brain of homozygous mice demonstrated that an aberrant transcript was made that spliced around the missing exons to generate an mRNA that maintained an in-frame deletion.
(J:44522)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Dnah11 Mutation: |
217 strains or lines available
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| Original: |
J:44522 Supp DM, et al., Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries. Development. 1999 Dec;126(23):5495-504 |
| All: |
1 reference(s) |
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Analysis Tools
