Col2a1<tm1Prc> Targeted Allele Detail MGI Mouse (MGI:2152978)

Col2a1^tm1Prc
Targeted Allele Detail

Summary

Symbol:	Col2a1^tm1Prc
Name:	collagen, type II, alpha 1; targeted mutation 1, Darwin J Prockop
MGI ID:	MGI:2152978
Gene:	Col2a1 Location: Chr15:97873483-97902525 bp, - strand Genetic Position: Chr15, 53.97 cM
Alliance:	Col2a1^tm1Prc page

Abnormal intervertebral disc development in Col2a1^tm1Prc/Col2a1^tm1Prc mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:30041
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A neomycin resistance cassette was inserted into exon 35. RT-PCR analysis demonstrated the presence of a transcript that terminated at exon 35. A mature protein was not detected in cultured cartilage cells isolated from homozygous mice. (J:30041)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	30 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Col2a1 Mutation:	69 strains or lines available

References

Original:	J:30041 Li SW, et al., Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone. Genes Dev. 1995 Nov 15;9(22):2821-30
All:	10 reference(s)

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