Neurl1atm1Led
Targeted Allele Detail
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| Symbol: |
Neurl1atm1Led |
| Name: |
neuralized E3 ubiquitin protein ligase 1A; targeted mutation 1, Philip Leder |
| MGI ID: |
MGI:2153143 |
| Gene: |
Neurl1a Location: Chr19:47167259-47247880 bp, + strand Genetic Position: Chr19, 39.39 cM
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| Alliance: |
Neurl1atm1Led page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:72105
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| Parent Cell Line: |
TC1/TC-1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutation: |
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Insertion
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Mutation details: Insertion of an IRES-GFP-PGK-neomycin resistance cassette into the exon encoding the NHR-2 region of the protein disrupted the gene and introduced transcriptional termination sequences downstream of the GFP coding sequences. Northern analyses of brain and skeletal muscle of homozygous mutant mice detected only aberrant transcripts using a 5' probe, and did not detect transcript using a 3' probe.
(J:72105)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Neurl1a Mutation: |
20 strains or lines available
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| Original: |
J:72105 Vollrath B, et al., Isolation of a Murine Homologue of the Drosophila neuralized Gene, a Gene Required for Axonemal Integrity in Spermatozoa and Terminal Maturation of the Mammary Gland. Mol Cell Biol. 2001 Nov;21(21):7481-94 |
| All: |
1 reference(s) |
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Analysis Tools
