Fgfr2tm1Cxd
Targeted Allele Detail
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| Symbol: |
Fgfr2tm1Cxd |
| Name: |
fibroblast growth factor receptor 2; targeted mutation 1, Chu-Xia Deng |
| MGI ID: |
MGI:2153790 |
| Synonyms: |
Fgfr2deltaIgIII, Fgfr2(DeltaIII) |
| Gene: |
Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
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| Alliance: |
Fgfr2tm1Cxd page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:46380
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| Parent Cell Line: |
TC1/TC-1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exons 7, 8 and 9 of the gene. These exons encode Ig domain IIIa, b and c. A mutant transcript that splices exon 6 in frame to exon 10 was detected by RT-PCR analysis, although at about one fifth of the wild-type levels. Western blot analysis revealed that a mutant protein is expressed in E10.5 homozygous embryos, but binding assays demonstrated that this mutant protein did not bind ligand.
(J:46380)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Fgfr2 Mutation: |
90 strains or lines available
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| Original: |
J:46380 Xu X, et al., Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development. 1998 Feb;125(4):753-65 |
| All: |
6 reference(s) |
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Analysis Tools
