About   Help   FAQ
Fgfr2tm1Lni
Targeted Allele Detail
Summary
Symbol: Fgfr2tm1Lni
Name: fibroblast growth factor receptor 2; targeted mutation 1, Peter Lonai
MGI ID: MGI:2153799
Synonyms: FGFR2-
Gene: Fgfr2  Location: Chr7:129764181-129868538 bp, - strand  Genetic Position: Chr7, 73.19 cM
Alliance: Fgfr2tm1Lni page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47643
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette in reverse orientation into exon 9, which encodes the IIIc Ig like loop of the ligand binding domain, replaced a ~10-13kb of sequence containing exons 10, 11, and part of exon 12. These exons encode the ATP binding site of the first kinase domain. (J:47643)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:  90 strains or lines available
References
Original:  J:47643 Arman E, et al., Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5082-7
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory