Fgfr2tm1.1Dsn
Targeted Allele Detail
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| Symbol: |
Fgfr2tm1.1Dsn |
| Name: |
fibroblast growth factor receptor 2; targeted mutation 1.1, Clive Dickson |
| MGI ID: |
MGI:2153811 |
| Synonyms: |
Fgfr2b-, Fgfr2(IIIb)-, FgfR2-IIIb-Cre |
| Gene: |
Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
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| Alliance: |
Fgfr2tm1.1Dsn page
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Palatal abnormalities in Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn and Fgf10tm1Wss/Fgf10tm1Wss mice
Show the 5 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:59285
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| Parent Cell Line: |
GK129 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Intragenic deletion
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Mutation details: This allele is a derivative of Fgfr2tm1Dsn in which exon IIIb was excised in the germline as follows: Cre recombinase was transiently expressed in fertilized C57BL/6 x Fgfr2tm1Dsn/tm1Dsn eggs by injection of an expression vector. Resulting progeny were screened for animals with a deletion of exon IIIb. Abnormally spliced transcripts are produced from this allele that splice exon IIIa to the transmembrane domain and the resulting frameshift is predicted to result in a termination codon in the transmembrane domain of the encoded protein. However, a normal IIIa to IIIc and TM transcript is made and is prediced to result in a normal isoform of the protein.
(J:59285)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Fgfr2 Mutation: |
90 strains or lines available
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| Original: |
J:59285 De Moerlooze L, et al., An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development. 2000 Feb;127(3):483-92 |
| All: |
24 reference(s) |
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Analysis Tools
