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Hand1tm1Jcc
Targeted Allele Detail
Summary
Symbol: Hand1tm1Jcc
Name: heart and neural crest derivatives expressed 1; targeted mutation 1, James C Cross
MGI ID: MGI:2153823
Synonyms: Hand1null
Gene: Hand1  Location: Chr11:57719539-57722973 bp, - strand  Genetic Position: Chr11, 35.27 cM
Alliance: Hand1tm1Jcc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46383
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A genomic fragment containing the entire coding region of the gene was replaced by a neomycin resistance expression cassette. (J:46383)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hand1 Mutation:  15 strains or lines available
Notes
Early mortality of homozygous embryos can be rescued by aggregation of mutant embryos with wild-type tetraploid embryos. By E10.5, embryos from tetrapoid chimeras die due to cardiac failure. The heart tubes show abnormal looping and ventricular myocardial differentiation. (J:46383)
References
Original:  J:46383 Riley P, et al., The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Nat Genet. 1998 Mar;18(3):271-5
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory