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Hand1tm1Eno
Targeted Allele Detail
Summary
Symbol: Hand1tm1Eno
Name: heart and neural crest derivatives expressed 1; targeted mutation 1, Eric N Olson
MGI ID: MGI:2153824
Synonyms: Hand1-, Hand1KO, Hand1lacZ
Gene: Hand1  Location: Chr11:57719539-57722973 bp, - strand  Genetic Position: Chr11, 35.27 cM
Alliance: Hand1tm1Eno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46384
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation details: A lacZ reporter gene followed by a neomycin resistance expression cassette was inserted in frame at the position of the initiation codon. (J:46384)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 69 assay results
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hand1 Mutation:  15 strains or lines available
References
Original:  J:46384 Firulli AB, et al., Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nat Genet. 1998 Mar;18(3):266-70
All:  11 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory