About   Help   FAQ
Pth1rtm1Hmk
Targeted Allele Detail
Summary
Symbol: Pth1rtm1Hmk
Name: parathyroid hormone 1 receptor; targeted mutation 1, Henry M Kronenberg
MGI ID: MGI:2154519
Synonyms: PTHrP receptor-
Gene: Pth1r  Location: Chr9:110551153-110576213 bp, - strand  Genetic Position: Chr9, 60.56 cM, cytoband F
Alliance: Pth1rtm1Hmk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:34604
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced exons E2 through T, which encode most of the receptor. In situ hybridization using a probe transcribed from rat receptor cDNA detected strong signal in four, and no signal in one, of five E9.5 embryos from heterozygous matings. (J:34604)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pth1r Mutation:  29 strains or lines available
References
Original:  J:34604 Lanske B, et al., PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth [see comments]. Science. 1996 Aug 2;273(5275):663-6
All:  21 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory