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Pth1rtm1Hmk
Targeted Allele Detail
Summary
Symbol: Pth1rtm1Hmk
Name: parathyroid hormone 1 receptor; targeted mutation 1, Henry M Kronenberg
MGI ID: MGI:2154519
Synonyms: PTHrP receptor-
Gene: Pth1r  Location: Chr9:110551153-110576213 bp, - strand  Genetic Position: Chr9, 60.56 cM, cytoband F
Alliance: Pth1rtm1Hmk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:34604
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced exons E2 through T, which encode most of the receptor. In situ hybridization using a probe transcribed from rat receptor cDNA detected strong signal in four, and no signal in one, of five E9.5 embryos from heterozygous matings. (J:34604)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pth1r Mutation:  29 strains or lines available
References
Original:  J:34604 Lanske B, et al., PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth [see comments]. Science. 1996 Aug 2;273(5275):663-6
All:  21 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory