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Tnrtm1Msch
Targeted Allele Detail
Summary
Symbol: Tnrtm1Msch
Name: tenascin R; targeted mutation 1, Melitta Schachner
MGI ID: MGI:2154583
Synonyms: tn-r-
Gene: Tnr  Location: Chr1:159351339-159759299 bp, + strand  Genetic Position: Chr1, 69.03 cM, cytoband E2
Alliance: Tnrtm1Msch page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55338
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A genomic fragment containing the coding region of exon 1 and part of intron 1 was replaced by a neomycin resistance cassette. Nothern blot and RT-PCR analysis demonstrated that an aberrant transcript is produced from this allele in total brain RNA from homozygous mice, but western blot analysis confirmed the absence of the protein in extracts derived from brains of homozygous mice. (J:55338)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnr Mutation:  65 strains or lines available
References
Original:  J:55338 Weber P, et al., Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS. J Neurosci. 1999 Jun 1;19(11):4245-62
All:  30 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory