Col11a2<tm1Mne> Targeted Allele Detail MGI Mouse (MGI:2154689)

Col11a2^tm1Mne
Targeted Allele Detail

Summary

Symbol:	Col11a2^tm1Mne
Name:	collagen, type XI, alpha 2; targeted mutation 1, Richard Mayne
MGI ID:	MGI:2154689
Gene:	Col11a2 Location: Chr17:34258411-34285659 bp, + strand Genetic Position: Chr17, 17.98 cM
Alliance:	Col11a2^tm1Mne page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:71948
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin-resistance cassette was inserted between restriction sites in exons 27 and 28. A short, aberrant trancript was produced from the targeted allele, which could be detected by Northern blotting. However, translation of the full-length protein is predicted to result in a truncated protein, due to the presence of termination codons. (J:71948)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Col11a2 Mutation:	63 strains or lines available

References

Original:	J:71948 Li SW, et al., Targeted disruption of Col11a2 produces a mild cartilage phenotype in transgenic mice: Comparison with the human disorder otospondylomegaepiphyseal dysplasia (OSMED). Dev Dyn. 2001 Oct;222(2):141-52
All:	4 reference(s)

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