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Ripk3 Gene Detail
Summary
  • Symbol
    Ripk3
  • Name
    receptor-interacting serine-threonine kinase 3
  • Synonyms
    2610528K09Rik, Rip3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2154952
    NCBI Gene: 56532
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56022452-56026314 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2154952
 protein coding gene Chr14:56022452-56026322 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021372
 protein coding gene Chr14:49830836-49834697 (-)
A/J MGP_AJ_G0021331
 protein coding gene Chr14:48843045-48846906 (-)
AKR/J MGP_AKRJ_G0021307
 protein coding gene Chr14:50590547-50594408 (-)
BALB/cJ MGP_BALBcJ_G0021335
 protein coding gene Chr14:48807567-48811428 (-)
C3H/HeJ MGP_C3HHeJ_G0021115
 protein coding gene Chr14:50279530-50283391 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021773
 protein coding gene Chr14:52324750-52328611 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019320
 protein coding gene Chr14:47208075-47211541 (-)
CAST/EiJ MGP_CASTEiJ_G0020634
 protein coding gene Chr14:46543427-46547291 (-)
CBA/J MGP_CBAJ_G0021082
 protein coding gene Chr14:53893784-53897645 (-)
DBA/2J MGP_DBA2J_G0021203
 protein coding gene Chr14:48558764-48562624 (-)
FVB/NJ MGP_FVBNJ_G0021185
 protein coding gene Chr14:48007150-48011010 (-)
LP/J MGP_LPJ_G0021277
 protein coding gene Chr14:50880415-50884276 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021209
 protein coding gene Chr14:53250788-53254648 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021800
 protein coding gene Chr14:49773449-49777310 (-)
PWK/PhJ MGP_PWKPhJ_G0020381
 protein coding gene Chr14:45092582-45096443 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020209
 protein coding gene Chr14:45777406-45781274 (-)
WSB/EiJ MGP_WSBEiJ_G0020687
 protein coding gene Chr14:50057696-50061556 (-)



Homology
more
  • Human Ortholog
    RIPK3, receptor interacting serine/threonine kinase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RIPK3, receptor interacting serine/threonine kinase 3
  • Synonyms
    RIP3
  • Links
    NCBI Gene ID: 11035
    neXtProt AC: NX_Q9Y572
    UniProt: Q9Y572

  • Chr Location
    14q12; chr14:24336025-24340022 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 6 alleles in 9 genetic backgrounds
    52 phenotypes from multigenic genotypes
    335 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for knock-out alleles exhibit resistance to induced inflammatory responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    98
  • GO References
    41
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    942
  • Tissues
    51
  • cDNA Data
    26
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56532 NCBI Gene Model | MGI Sequence Detail 3863 C57BL/6J ±  kb
    transcript NM_001164108 RefSeq | MGI Sequence Detail 1980 C57BL/6  
    polypeptide Q9QZL0 UniProt | EBI | MGI Sequence Detail 486 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 26
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1923812, MGI:2145796
    References
    more
    • Summaries
      All 459
      Developmental Gene Expression 31
      Gene Ontology 41
      Phenotypes 335
    • Earliest
      J:57772 Pazdernik NJ, et al., Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB. Mol Cell Biol. 1999 Oct;19(10):6500-8
    • Latest
      J:349811 Mannion J, et al., A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death. Immunity. 2024 May 15;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory