Myo7a<4626SB> Chemically induced Allele Detail MGI Mouse (MGI:2155422)

Myo7a^4626SB
Chemically induced Allele Detail

Summary

Symbol:	Myo7a^4626SB
Name:	myosin VIIA; shaker 4626SB
MGI ID:	MGI:2155422
Synonyms:	Myo7a^sh1-5R, sh1^4626SB, sh1^OR-4626SB, shaker-1
Gene:	Myo7a Location: Chr7:97700267-97768731 bp, - strand Genetic Position: Chr7, 53.57 cM
Alliance:	Myo7a^4626SB page

Cochlear hair cell abnormalities in Myo7a^Hdb/Myo7a⁺, Myo7a^Hdb/Myo7a⁺ Myo7a^4626SB/Myo7a⁺, and Myo7a^sh1/Myo7a^sh1 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

BALB/cRl

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Single point mutation
		Mutation details: A C-to-T transition mutation is predicted to result in a glutamine to stop codon change at position 720 in the encoded protein. This mutation is predicted to lie within the head domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that less than 1% of the normal level of the protein was expressed. (J:49926)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Myo7a Mutation:	118 strains or lines available

References

Original:	J:54592 Rinchik EM, et al., N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations. Genetics. 1999 May;152(1):373-83
All:	26 reference(s)

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