Myo7a<816SB> Chemically induced Allele Detail MGI Mouse (MGI:2155423)

Myo7a^816SB
Chemically induced Allele Detail

Summary

Symbol:	Myo7a^816SB
Name:	myosin VIIA; shaker 816SB
MGI ID:	MGI:2155423
Synonyms:	Myo7a^sh1-2R, sh1^816SB, sh1^OR-816SB
Gene:	Myo7a Location: Chr7:97700267-97768731 bp, - strand Genetic Position: Chr7, 53.57 cM
Alliance:	Myo7a^816SB page

Mutation
origin

Strain of Origin:

BALB/cRl

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutations:		Insertion, Inversion
		Mutation details: A 16 nt inversion and substitution of two A nucleotides with a single G resulted in a deletion of ten amino acids in the encoded protein. This mutation is predicted to lie in the head domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that approximately 63% of the normal level of the protein was expressed. (J:49926)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Myo7a Mutation:	118 strains or lines available

References

Original:	J:10283 Rinchik EM, et al., A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis. Proc Natl Acad Sci U S A. 1990 Feb;87(3):896-900
All:	7 reference(s)

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