Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol: Acvrl1tm1Enl Name: activin A receptor, type II-like 1; targeted mutation 1, En Li MGI ID: MGI:2155980 Synonyms: Acvrl1-, ALK1-, Alk1neo Gene: Acvrl1  Location: Chr15:101026403-101043217 bp, + strand  Genetic Position: Chr15, 56.41 cM, cytoband F3 Alliance: Acvrl1tm1Enl page

Abnormal yolk sac and embryo morphology of Acvrl1tm1Enl/Acvrl1tm1Enl mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:61177
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion     A PGK-neomycin selection cassette was inserted into exon 8, which encodes kinase subdomain V. (J:61177)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	18 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acvrl1 Mutation:	27 strains or lines available

Original:	J:61177 Oh SP, et al., Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2626-31
All:	13 reference(s)