Adora2a<tm1Jfc> Targeted Allele Detail MGI Mouse (MGI:2155985)

Adora2a^tm1Jfc
Targeted Allele Detail

Summary

Symbol:	Adora2a^tm1Jfc
Name:	adenosine A2a receptor; targeted mutation 1, Jiang-Fan Chen
MGI ID:	MGI:2155985
Synonyms:	A2A, A2AAR^-, A2A KO, A2aR-, A2AR KO, Adora2a^tm1Chren, gKO
Gene:	Adora2a Location: Chr10:75152711-75170618 bp, + strand Genetic Position: Chr10, 38.52 cM, cytoband B5.3
Alliance:	Adora2a^tm1Jfc page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:73594
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Part of exon 2 and intron 2 was replaced by a neomycin selection cassette. The absence of functional protein was demonstrated in homozygous mice by in situ binding assays and neurochemical tests. (J:73594)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Adora2a Mutation:	40 strains or lines available

References

Original:	J:73594 Chen JF, et al., A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. J Neurosci. 1999 Nov 1;19(21):9192-200
All:	150 reference(s)

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