Caln1 MGI Mouse Gene Detail - MGI:2155987

Symbol

Caln1
Name

calneuron 1
Synonyms

9630012C17Rik, Cabp8

Feature Type

protein coding gene
IDs

MGI:2155987
NCBI Gene: 140904
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr5:130398296-130876253 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 69.29 cM, cytoband F
Mapping Data

3 experiments

SNPs within 2kb

14300 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2155987	protein coding gene	Chr5:130398245-130876253 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030146	protein coding gene	Chr5:134512707-135045705 (+)
A/J	MGP_AJ_G0030114	protein coding gene	Chr5:128829121-129318135 (+)
AKR/J	MGP_AKRJ_G0030047	protein coding gene	Chr5:133011107-133516067 (+)
BALB/cJ	MGP_BALBcJ_G0030124	protein coding gene	Chr5:130183359-130664598 (+)
C3H/HeJ	MGP_C3HHeJ_G0029840	protein coding gene	Chr5:133578861-134090193 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030577	protein coding gene	Chr5:139661281-140189439 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027802	protein coding gene	Chr5:123208483-123686408 (+)
CAST/EiJ	MGP_CASTEiJ_G0029250	protein coding gene	Chr5:132907520-133430744 (+)
CBA/J	MGP_CBAJ_G0029810	protein coding gene	Chr5:145095680-145687893 (+)
DBA/2J	MGP_DBA2J_G0029961	protein coding gene	Chr5:128792742-129274067 (+)
FVB/NJ	MGP_FVBNJ_G0029916	protein coding gene	Chr5:127885619-128374442 (+)
LP/J	MGP_LPJ_G0030049	protein coding gene	Chr5:135016854-135550168 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029948	protein coding gene	Chr5:148422968-148949379 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030617	protein coding gene	Chr5:132705407-133227025 (+)
PWK/PhJ	MGP_PWKPhJ_G0028964	protein coding gene	Chr5:127735542-128246861 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028800	protein coding gene	Chr5:130283020-130814104 (+)
WSB/EiJ	MGP_WSBEiJ_G0029323	protein coding gene	Chr5:133422749-133939195 (+)

Human Ortholog

CALN1, calneuron 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CALN1, calneuron 1
Synonyms

CABP8
Links

HGNC:13248

NCBI Gene ID: 83698

neXtProt AC: NX_Q9BXU9

UniProt: Q9BXU9
Chr Location

7q11.22; chr7:71779491-72504279 (-) GRCh38

MGI Vertebrate Homology

Caln1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CALN1
Gene Tree

Caln1

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Caln1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit fewer Golgi satellites and decreased levels of polysialylation of NCAM in distal dendrites of hippocampal CA1 neurons that receive input from the temporoammonic pathway and reduced long-term potentiation at distal synapses.

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All GO Annotations

7
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

763
Tissues

33
cDNA Data

13
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CALN1

Xenbase caln1

ZFIN caln1

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All Sequences

74
RefSeq

24
UniProt

5
CCDS

CCDS19714.1, CCDS51656.1

Ensembl

ENSMUSG00000060371 (Evidence)
NCBI Gene

140904

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060371	Ensembl Gene Model \| MGI Sequence Detail	477958	C57BL/6J	± kb
transcript	ENSMUST00000086029	Ensembl \| MGI Sequence Detail	1801	Not Applicable
polypeptide	ENSMUSP00000083193	Ensembl \| MGI Sequence Detail	261	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004983 calcium-binding protein 8

(term hierarchy)
InterPro Domains

IPR051111 Calcium-binding regulatory protein

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR001751 S100/Calcium binding protein 7/8-like, conserved site

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All nucleic 13

cDNA 13

Microarray probesets 3

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MGI:2444767

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 10
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:338143 Andres-Alonso M, et al., Golgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses. Cell Rep. 2023 Jun 23;42(7):112692

TSS for Caln1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49058	Chr5:130398088-130398130 (+)	-187 bp
Tssr49059	Chr5:130398248-130398258 (+)	-43 bp
Tssr49060	Chr5:130398261-130398315 (+)	-8 bp
Tssr49061	Chr5:130398322-130398336 (+)	33 bp
Tssr49062	Chr5:130398363-130398366 (+)	69 bp
Tssr49063	Chr5:130413406-130413429 (+)	15,122 bp
Tssr49064	Chr5:130413533-130413558 (+)	15,250 bp
Tssr49065	Chr5:130413559-130413601 (+)	15,284 bp
Tssr49066	Chr5:130477656-130477671 (+)	79,368 bp
Tssr49067	Chr5:130477677-130477697 (+)	79,391 bp
Tssr49068	Chr5:130478215-130478279 (+)	79,951 bp
Tssr49069	Chr5:130536930-130536940 (+)	138,639 bp
Tssr49070	Chr5:130706401-130706402 (+)	308,106 bp
Tssr49071	Chr5:130865605-130865609 (+)	467,311 bp
Tssr49072	Chr5:130873936-130873948 (+)	475,646 bp
Tssr49073	Chr5:130873960-130873982 (+)	475,675 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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