H2ax<tm1Nus> Targeted Allele Detail MGI Mouse (MGI:2156048)

H2ax^tm1Nus
Targeted Allele Detail

Summary

Symbol:	H2ax^tm1Nus
Name:	H2A.X variant histone; targeted mutation 1, Andre Nussenzweig
MGI ID:	MGI:2156048
Synonyms:	H2AX-, H2AX^delta
Gene:	H2ax Location: Chr9:44246012-44247374 bp, + strand Genetic Position: Chr9, 24.84 cM
Alliance:	H2ax^tm1Nus page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:73342
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		A neomycin resistance cassette replaced an AscI-XhoI segment of coding sequence. (J:73342)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying H2ax^tm1Nus

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any H2ax Mutation:	7 strains or lines available

References

Original:	J:73342 Petersen S, et al., AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature. 2001 Dec 6;414(6864):660-5
All:	30 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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