Lrp6<Gt(Ex187)Byg> Gene trapped Allele Detail MGI Mouse (MGI:2156191)

Lrp6^Gt(Ex187)Byg
Gene trapped Allele Detail

Summary

Symbol:	Lrp6^Gt(Ex187)Byg
Name:	low density lipoprotein receptor-related protein 6; gene trap Ex187, BayGenomics
MGI ID:	MGI:2156191
Synonyms:	lrp6-, Lrp6^betageo, Lrp6^{Gt(pGT1.8TM)187Wcs}, Lrp6^lacZ
Gene:	Lrp6 Location: Chr6:134423439-134543876 bp, - strand Genetic Position: Chr6, 65.37 cM
Alliance:	Lrp6^Gt(Ex187)Byg page

Lrp6^Cd/Lrp6^Gt(Ex187)Byg mice reveal a range of phenotypes

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Mutant Cell Line:	Ex187
Germline Transmission:	Earliest citation of germline transmission: J:64989
Parent Cell Line:	CGR8 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT1.8TM

Mutation details: Insertion of a gene trap vector into the gene that joined the first 321 amino acids of the encoded protein in frame to a beta-galactosidase-neomycin resistance reporter gene. Northern blot analysis demonstrated that no normal transcript was encoded by this allele. (J:64989)

Inheritance:

Recessive

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	79 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Lrp6 Mutation:	95 strains or lines available

References

Original:	J:37528 Skarnes WC, et al., Capturing genes encoding membrane and secreted proteins important for mouse development. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6592-6
All:	44 reference(s)

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