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Elovl6 Gene Detail
Summary
  • Symbol
    Elovl6
  • Name
    ELOVL fatty acid elongase 6
  • Synonyms
    ELOVL family member 6, elongation of long chain fatty acids (yeast), FEN1/Elo2, SUR4/Elo3-like, LCE
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156528
    NCBI Gene: 170439
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:129326035-129432144 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 58.05 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3329 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2156528
 protein coding gene Chr3:129326004-129432144 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027870
 protein coding gene Chr3:132193009-132297133 (+)
A/J MGP_AJ_G0027828
 protein coding gene Chr3:127606501-127712663 (+)
AKR/J MGP_AKRJ_G0027793
 protein coding gene Chr3:130912962-131018730 (+)
BALB/cJ MGP_BALBcJ_G0027841
 protein coding gene Chr3:127444021-127549604 (+)
C3H/HeJ MGP_C3HHeJ_G0027570
 protein coding gene Chr3:131302128-131407760 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028285
 protein coding gene Chr3:136930382-137046029 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025623
 protein coding gene Chr3:123130060-123236963 (+)
CAST/EiJ MGP_CASTEiJ_G0027027
 protein coding gene Chr3:130969502-131089384 (+)
CBA/J MGP_CBAJ_G0027546
 protein coding gene Chr3:141553990-141659614 (+)
DBA/2J MGP_DBA2J_G0027687
 protein coding gene Chr3:126795783-126901588 (+)
FVB/NJ MGP_FVBNJ_G0027654
 protein coding gene Chr3:124372244-124478631 (+)
LP/J MGP_LPJ_G0027796
 protein coding gene Chr3:133709139-133815568 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027685
 protein coding gene Chr3:149499178-149601042 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028342
 protein coding gene Chr3:130574419-130688143 (+)
PWK/PhJ MGP_PWKPhJ_G0026751
 protein coding gene Chr3:126524808-126632076 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026576
 protein coding gene Chr3:128637032-128744178 (+)
WSB/EiJ MGP_WSBEiJ_G0027106
 protein coding gene Chr3:131283590-131392355 (+)



Homology
more
  • Human Ortholog
    ELOVL6, ELOVL fatty acid elongase 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELOVL6, ELOVL fatty acid elongase 6
  • Synonyms
    FACE, FAE, hELO2, LCE
  • Links
    NCBI Gene ID: 79071
    neXtProt AC: NX_Q9H5J4
    UniProt: Q9H5J4

  • Chr Location
    4q25; chr4:110045846-110199202 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null gene trap mutation exhibit enhanced motor coordination. Female homozygotes exhibit decreased serum cholesterol levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    845
  • Tissues
    133
  • cDNA Data
    168
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 170439 NCBI Gene Model | MGI Sequence Detail 106110 C57BL/6J ±  kb
    transcript NM_130450 RefSeq | MGI Sequence Detail 5951 C57BL/6  
    polypeptide Q920L5 UniProt | EBI | MGI Sequence Detail 267 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 174
      cDNA 169
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140052
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 11
      Phenotypes 33
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory