Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Pax63Neu
Name:	paired box 6; 3, Neuherberg
MGI ID:	MGI:2156742
Synonyms:	Enu-65, ENU-65
Gene:	Pax6  Location: Chr2:105499245-105527709 bp, + strand  Genetic Position: Chr2, 55.31 cM
Alliance:	Pax63Neu page

Strain of Origin:

(102 x C3H)F1

Allele Type:    Chemically induced (ENU) Mutation:    Insertion   Mutation details: The mutation was identified as the insertion of single nucleotide (A) In exon 7 following Nucleotide 598. The frameshift results in normal protein through codon 145 of exon 7 followed by 12 aberrant amino acids and a premature stop codon. The linker region, homeodomain, and P/S/T domains are all deleted in the resulting protein. (J:73625)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pax6 Mutation:	94 strains or lines available

Original:	J:21950 Favor J, A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983 Aug;110(2):367-82
All:	5 reference(s)