Coq7<tm1Hek> Targeted Allele Detail MGI Mouse (MGI:2157003)

Coq7^tm1Hek
Targeted Allele Detail

Summary

Symbol:	Coq7^tm1Hek
Name:	demethyl-Q 7; targeted mutation 1, Siegfried Hekimi
MGI ID:	MGI:2157003
Synonyms:	mclk1-
Gene:	Coq7 Location: Chr7:118108881-118132529 bp, - strand Genetic Position: Chr7, 63.44 cM
Alliance:	Coq7^tm1Hek page

Severe developmental delay in Coq7^tm1Hek/Coq7^tm1Hek embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:73121
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance cassette replaced part of exon II and all of exons III and IV. Northern blot analysis using a full length cDNA probe did not detect transcript in homozygous mutant E11.5 embryos. Immunoblot analysis using a polyclonal antibody detected a 21kDa band in liver and brain that was reduced by 50% in heterozygote mice compared with wild-type mice. (J:73121)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Coq7 Mutation:	29 strains or lines available

References

Original:	J:73121 Levavasseur F, et al., Ubiquinone is necessary for mouse embryonic development but is not essential for mitochondrial respiration. J Biol Chem. 2001 Dec 7;276(49):46160-4
All:	10 reference(s)

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