Apobtm5Sgy
Targeted Allele Detail
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| Symbol: |
Apobtm5Sgy |
| Name: |
apolipoprotein B; targeted mutation 5, Stephen G Young |
| MGI ID: |
MGI:2157108 |
| Synonyms: |
apob39 |
| Gene: |
Apob Location: Chr12:8027648-8066835 bp, + strand Genetic Position: Chr12, 3.53 cM
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| Alliance: |
Apobtm5Sgy page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:51549
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| Parent Cell Line: |
RF8 (ES Cell)
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| Strain of Origin: |
129S4/SvJae
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: An insertion-type vector was used to create mutations in exon 26 at codon 1785 to alter this residue from an asparagine to a stop codon (N1785X). Western blot analysis on plasma derived from heterozygous and homozygous mice demostrated that a mutant, truncated protein is expressed from this allele, and the expression of the ApoB48 and ApoB100 isoforms was abolished.
(J:51549)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Apob Mutation: |
224 strains or lines available
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| Original: |
J:51549 Kim E, et al., A gene-targeted mouse model for familial hypobetalipoproteinemia. Low levels of apolipoprotein B mRNA in association with a nonsense mutation in exon 26 of the apolipoprotein B gene. J Biol Chem. 1998 Dec 18;273(51):33977-84 |
| All: |
1 reference(s) |
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Analysis Tools
