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Apoa2tm1Bres
Targeted Allele Detail
Summary
Symbol: Apoa2tm1Bres
Name: apolipoprotein A-II; targeted mutation 1, Jan L Breslow
MGI ID: MGI:2157148
Synonyms: apoA-II -
Gene: Apoa2  Location: Chr1:171052623-171053948 bp, + strand  Genetic Position: Chr1, 79.22 cM
Alliance: Apoa2tm1Bres page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:37250
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A genomic fragment containing exons 1-3 and part of exon 4 was replaced with a neomycin selection cassette. Northern blot analysis on total liver RNA demonstrated that the transcript was not detectable in homozygous mice, and the encoded protein was not detected in HDL isolates of plasma derived from homozygous mice. (J:37250)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Apoa2 Mutation:  20 strains or lines available
References
Original:  J:37250 Weng W, et al., Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14788-94
All:  9 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory