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Il1atm1Yiw
Targeted Allele Detail
Summary
Symbol: Il1atm1Yiw
Name: interleukin 1 alpha; targeted mutation 1, Yoichiro Iwakura
MGI ID: MGI:2157371
Synonyms: IL-1alpha-, IL-1alpha KO
Gene: Il1a  Location: Chr2:129141530-129151892 bp, - strand  Genetic Position: Chr2, 62.9 cM, cytoband F
Alliance: Il1atm1Yiw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47429
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A lacZ-PGK-hygromycin expression cassette replaced 1.5kb of sequence, including the region in exon 5 that encodes the amino terminal region of the mature protein. Northern blot analysis of activated peritoneal macrophages did not detect transcript in homozygous mutant mice. (J:47429, J:92002)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il1a Mutation:  30 strains or lines available
References
Original:  J:47429 Horai R, et al., Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med. 1998 May 4;187(9):1463-75
All:  171 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory