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Il1rntm1Yiw
Targeted Allele Detail
Summary
Symbol: Il1rntm1Yiw
Name: interleukin 1 receptor antagonist; targeted mutation 1, Yoichiro Iwakura
MGI ID: MGI:2157397
Synonyms: IL-1Ra-, IL-1ra KO
Gene: Il1rn  Location: Chr2:24226872-24241503 bp, + strand  Genetic Position: Chr2, 16.36 cM
Alliance: Il1rntm1Yiw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47429
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A PGK-neomycin resistance cassette replaced all the coding regions for the secreted form of the protein. Northern blot analysis of activated peritoneal macrophages did not detect transcript in homozygous mutant mice. (J:47429)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il1rn Mutation:  23 strains or lines available
References
Original:  J:47429 Horai R, et al., Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med. 1998 May 4;187(9):1463-75
All:  50 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/19/2024
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