Ift88<Tg737Rpw> Transgenic Allele Detail MGI Mouse (MGI:2157527)

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Ift88^Tg737Rpw
Transgenic Allele Detail

Summary | Transgene origin | Transgene description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Ift88^Tg737Rpw
Name:	intraflagellar transport 88; transgene insertion 737, Richard P Woychik
MGI ID:	MGI:2157527
Synonyms:	Ift88^orpk, orpk, Tg737(o)(rpk), Tg737^orpk, Tg737^orpk, Tg737Rpw, TgN737Rpw, TgN(Imorpk)737Rpw
Gene:	Ift88 Location: Chr14:57661519-57755393 bp, + strand Genetic Position: Chr14, 30.1 cM
Alliance:	Ift88^Tg737Rpw page

Transgene
origin

Strain of Origin:

FVB/N

Transgene
description

Transgene Type:		Transgenic
Mutation:		Insertion
		Mutation details: A random transgene insertional event resulted in the deletion of approximately 2.7kb at the transgene insertion site in an intron of the gene, but no exons were deleted. Northern blot analysis revealed that expression of a 3.2 and 7.0kb transcript was abolished in RNA from all tissues derived from homozygous mice. The allele is hypomorphic. (J:18508)
Inheritance:		Not Specified

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ift88 Mutation:	48 strains or lines available

References

Original:	J:18508 Moyer JH, et al., Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science. 1994 May 27;264(5163):1329-33
All:	51 reference(s)

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