Itgamtm1Bll
Targeted Allele Detail
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| Symbol: |
Itgamtm1Bll |
| Name: |
integrin alpha M; targeted mutation 1, Christie M Ballantyne |
| MGI ID: |
MGI:2157556 |
| Synonyms: |
CD11b-, CR3-, CR3/MAC-1-, deltaalphaM, Mac-1- |
| Gene: |
Itgam Location: Chr7:127661812-127717663 bp, + strand Genetic Position: Chr7, 69.93 cM, cytoband F4
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| Alliance: |
Itgamtm1Bll page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:39092
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| Parent Cell Line: |
AB2.1 (ES Cell)
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| Strain of Origin: |
129S7/SvEvBrd-Hprt1b-m2
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 0.7kb genomic fragment containing exon 4 was replaced with a neomycin selection cassette. RT-PCR and RNAse protection assays demonstrated that a mutant transcript is produced from this allele that splices exon 3 to exon 5, which results in a frameshift mutation. Immunohistochemistry analysis revealed that no encoded protein was detectable in spleen sections from homozygous mice.
(J:39092)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Itgam Mutation: |
48 strains or lines available
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| Original: |
J:39092 Lu H, et al., LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice. J Clin Invest. 1997 Mar 15;99(6):1340-50 |
| All: |
54 reference(s) |
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Analysis Tools
